Editorial: Phase III Elimination: Another Two-Edged Sword
نویسندگان
چکیده
منابع مشابه
Phase III elimination: another two-edge sword.
Excretion into bile is well recognized as a major pathway for the elimination of amphipathic, hydrophobic, high molecular weight xenobiotics and thus complements the renal elimination of hydrophilic compounds of low molecular weight. For many xeno-biotics, excretion in bile, which has been termed a phase III elimination reaction (1), begins with an oxidation reaction (phase I), followed by conj...
متن کاملThe two-edged sword.
Unlike most chronic illnesses which have been declining or stabilizing in prevalence, incidence of type 2 diabetes has been increasing in the Western Hemisphere, and is now increasing at alarming rates in Asia1. While all causes of these increases cannot be identified, without question the increase in adiposity is an important contributor. The latter is due to increased caloric intake and reduc...
متن کاملSuperoxide: a two-edged sword
Superoxide (O2 ) is the compound obtained when oxygen is reduced by one electron. For a molecule with an unpaired electron, O2 is surprisingly inert, its chief reaction being a dismutation in which it reacts with itself to form H2O2 and oxygen. The involvement of O2 in biological systems was first revealed by the discovery in 1969 of superoxide dismutase, an enzyme that catalyzes the dismutatio...
متن کاملBRAF inhibitors: two edged sword
Somatic mutations in BRAF occur in two thirds of cutaneous melanomas, leading to the activation of the RAF-MEK-ERK signalling pathway. Preclinical studies of BRAF mutations showed that inhibition of BRAF led to melanoma cell proliferation inhibition and apoptosis induction in vitro and blockade of melanoma xenograft growth in vivo. Clinical studies of BRAF inhibitors in BRAF-mutated metastatic ...
متن کاملA Double-Edged Sword?
The enormous benefits of inhibition of ACE demonstrate that manipulation of the metabolism of peptide hormones is a valuable therapeutic strategy for cardiovascular disease. Recent attempts to expand these benefits have combined ACE inhibition with inhibition of other peptidases such as neutral endopeptidase (NEP) in a single molecule, a strategy known as vasopeptidase inhibition. NEP metaboliz...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1994
ISSN: 0091-6765
DOI: 10.2307/3432028